Linked to Alzheimer’s Disease Risk



The relationship between Low Testosterone and Alzheimer’s has been conjectured for a long time but now, it is largely believed that low levels of testosterone hormone has a direct relation between age-related dementia and associated conditions like neurological disorders alzheimer’s disease. Please note that Alzheimer’s disease itself is essentially a progressive form of age-related dementia. It is caused by increasingly deteriorating tissue of the brain. In fact, most cases of Alzheimer’s disease seem to suggest falling levels of sexual hormones like testosterone at some point, i.e. preceding the onset of this condition or during its progressing phase. This relationship is essentially because Testosterone is the primary sex hormone among males though it plays quite a critical role in the overall sexual health of women too.

Decoding Relation Between Low Testosterone Levels and Alzheimer’s Disease

Among men, testosterone levels tend to rise significantly during and after puberty and tend to start declining around the 40 onwards. Most researchers who support the link between Alzheimer’s and Testosterone opine that that low testosterone levels are a contributory factor in the excessive accumulation of plaques of beta-amyloid in the brain tissue. This sort of plaque development is responsible for the brain tissue damage that is associated with Alzheimer’s disease. However, testosterone exists in various forms in the human body. The particular kind of testosterone that seems to have a role in the onset and progression of Alzheimer’s is essentially ‘Free Testosterone’—this is the hormone found circulating in the bloodstream.

Free Testosterone got its nomenclature from the fact that it exists totally unattached to any of the binding proteins. This means that it is readily available for usage by the cellular mechanism that is at the core of human tissue, including brain tissue. Free testosterone levels are also required for maintaining the overall immunity, sexual health and appropriate libido among men apart from neutralizing the body’s aging process. This is why dipping levels of testosterone and Alzheimer’s disease seem to progress in a typical pattern (i.e. simultaneously) among the elderly. Again, testosterone plays a significant role in supporting many of the cognitive functions of men and declining levels of testosterone during old age lead to reduced cognitive abilities. Reduced intellectual functions are also associated with Alzheimer’s and old age, including issues such as reduced memory retention and learning/comprehension problems.

Testosterone Replacement Therapy

Perhaps, the biggest proof of this theory is that Alzheimer’s is often treated with a basic degree of testosterone replacement therapy. It should be noted that Testosterone Replacement Therapy is not a cure for Alzheimer’s and neither does it promise to stall the progress of this condition. However, this therapy has worked in alleviating the symptoms of Alzheimer’s patients apart from slowing down the onset of
Alzheimer’s in men when extremely low testosterone levels are established at an early stage through timely clinical testing. In other cognitive problems among middle-aged men, some form of supplemental testosterone has shown to have a largely positive effect to the extent of curing depression and memory-loss issues. Even if testosterone supplementation is not the perfect treatment for Alzheimer’s, it is known to have largely beneficial effects in the management of Alzheimer’s patients, helping them to improve the quality of their life in an appreciable manner. Further, testosterone treatment can improve the spatial performance of Alzheimer’s patients—further proving a definite connection between Low Testosterone and Alzheimer’s.

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